The reference site for Sulfamethoxazole

Sulfamethoxazole (SMZ or SMX), is an antibiotic. It was used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis

WHAT IS SULFAMETHOXAZOLE?

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic. Sulfonamides (sulfa drugs) are antibiotics used to treat a wide variety of bacterial infections such as urinary tract infections, bronchitis, ear infections (otitis), traveler’s diarrhea, and Pneumocystis carinii pneumonia in AIDS or cancer patients.

It is most often used as part of a synergistic combination with trimethoprim in a 5:1 ratio in co-trimoxazole, which is more commonly known by its brand names Bactrim®, Septra® and Sulfatrim®.

Additionally, it can also be used as an alternative to amoxicillin-based antibiotics to treat sinusitis.

 

Brand Name(s): Bactrim; Septra; Sulfatrim
CAS nº: 723-46-6
(sul fa meth OX a zole)

 

Product Info

The sections below will provide you with more specific information and guidelines related to sulfamethoxazole and its correct use. Please read them carefully.

FDA Information

Sulfamethoxazole was first approved by the Food and Drug Administration in 1961.

Following this, the sulfamethoxazole-trimethoprim combination was later approved by the FDA on June 23rd 1981, for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), a common OI in people with HIV.

A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic. Sulfonamides (sulfa drugs) are antibiotics used to treat a wide variety of bacterial infections such as urinary tract infections, bronchitis, ear infections (otitis), traveler’s diarrhea, and Pneumocystis carinii pneumonia in AIDS or cancer patients.

It is most often used as part of a synergistic combination with trimethoprim in a 5:1 ratio in co-trimoxazole, and can be found under several brand names including Bactrim®Septra®, and Sulfatrim®.

This medication can also be used as an alternative to amoxicillin-based antibiotics to treat sinusitis.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Sulfamethoxazole comes as a tablet or liquid suspension to be taken orally.

Take each tablet dose with a full glass of water, and continue to drink plenty of water while on this medication.

The liquid suspension form of this medicine must be shaken well before each use.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Do this by taking the medication at evenly spaced intervals throughout the day and night.

Continue to take this medication until the full prescribed amount is finished even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow resulting in a relapse of the infection.

What special precautions should I follow?

BEFORE TAKING SULFAMETHOXAZOLE:

Tell your doctor your medical history including liver or kidney disease, blood disorders, or any drug allergies.

Please inform your doctor of all the medicines you may be using (both prescription and non-prescription), especially if you are taking warfarin, methotrexate, cyclosporine, certain oral drugs for diabetes (sulfonylureas), phenytoin, or oral PABA.

Moreover, this drug may interfere with the effectiveness of birth control pills. Discuss using other methods of birth control with your doctor.

Do not start or stop any medicine without doctor or pharmacist approval.

This medicine may make you more prone to sunburn. Wear protective clothing and a sunscreen when outdoors.

Additionally, this medication should be used only if clearly needed during pregnancy. Also, this drug is excreted into breast milk and may have an effect on a nursing infant. Discuss the risks and benefits with your doctor.

What should I do if I forget a dose?

If you should miss a dose, take it as soon as remembered unless it is almost time for the next dose. If it is nearly time for the next dose, skip the missed dose and resume your usual dosing schedule.

It is strongly advised never to “double-up” the dose.

What side effects can this medication cause?

Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. However, sulfamethoxazole may cause stomach upset, diarrhea, nausea, headache or vomiting during the first few days as your body adjusts to the medication. If these symptoms persist or become severe, inform your doctor.

This drug may increase sensitivity to sunlight.

Notify your doctor if your condition worsens or you develop easy bruising.

Rarely, this medication can cause serious, even fatal, side effects such as a severe peeling skin rash known as Stevens-Johnson syndrome, blood disorders (e.g., agranulocytosis, aplastic anemia), or liver damage. Seek immediate medical attention if you develop any of the following symptoms:

skin rash or blisters
unusual fatigue
persistent sore throat or fever
yellowing eyes or skin
dark urine
abdominal pain

In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms of an allergic reaction include:

rash
itching
swelling
dizziness
trouble breathing

If you notice other effects not listed above, contact your doctor or pharmacist.

What storage conditions are needed for this medicine?

Try to keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze the liquid form of sulfamethoxazole.

Please remember to throw away any medication that is outdated or no longer needed. If it is necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911.

Symptoms of overdose may include:

loss of appetite
nausea/vomiting
dizziness
headache
drowsiness
unconsciousness
fever
pain while urinating
bruising

Product Images

PICTURES OF SULFAMETHOXAZOLE PRODUCTS

Below you will find images and specific information on the principal types of sulfamethoxazole that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: BACTRIM® SYRUP
Strength(s): 200 / 40 MG
Imprint: BACTRIM 100 ML SYRUP
Manufacturer: ROCHE LABS.

Name: SEPTRA®
Strength(s): 400 / 80 MG
Imprint: SEPTRA Y28
Manufacturer: KING PHARMACEUTICALS

Name: BACTRIM®
Strength(s): 400 / 80 MG
Imprint: BACTRIM
Manufacturer: ROCHE LABS.

Name: BACTRIM-DS®
Strength(s): 800 / 160 MG
Imprint: BACTRIM DS | WF HC
Manufacturer: WOMEN FIRST HEALTHCARE INC.
Distributors: PHYSICIANS TOTALCARE INC.
                   WAL MART STORE INC.

Name: SEPTRA-DS®
Strength(s): 800 / 160 MG
Imprint: SEPTRA DS | O2C
Manufacturer: MONARCH PHARMACEUTICALS
Distributor: WAL MART STORES INC.

Name: BACTRIM-DS®
Strength(s): 800 / 160 MG
Imprint: BACTRIM DS
Manufacturer: ROCHE LABS.

Name: SULFAMETHOXAZOLE
Strength(s): 800 / 160 MG
Imprint: MP 85
Manufacturer: URL / MUTUAL PHARMACEUTICALS

Name: SULFAMETHOXAZOLE
Strength(s): 800 / 160 MG
Imprint: 93 089
Manufacturer: TEVA USA.

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